I would recommend using it with any distro, it’s distro agnostic

Depends. Do you have knee highs?

I would only recommend using it if a native package is not available or you need a newer version than what’s available.

Half the time I will just compile from source when I see how much space a flatpak and its dependencies will take up though.

It’s really good, the only thing I’d complain about is that sometimes it takes up large amounts of space. Aside from that it is not bad in the least