nah. loam is, for example, 40% sand, 20% clay, 40% silt and it’s close to middle of that polygon, on top of letter O
for example, draw a line from 50% sand point on edge to 50% clay point on edge, the first one is 50% sand 50% silt because that axis for sand is also 0% for clay, the second one is 50% sand 50% clay because it lies at the line that is 0% silt
if you have to tell people that you’re enlightened, you ain’t
also why have you picked vaccines in particular. maybe you wanted to express something else more clearly? there’s no money in vaccines to such degree that western pharma companies don’t want to research them, and bulk of (non-mRNA) vaccines are made in Serum Institute of India, they make this stuff for half of the world if not more. this thing is cheeaap, and because it’s a preventive one and done you can take it on your own terms, you’re not under time pressure to get it so you can shop around to get it cheaply. you can’t nickel and dime people on vaccines
now if you do want to nickel and dime a patient, you’d need something that they’re gonna need forever and jack up prices or just keep them high from day one, like with antiretrovirals or what purdue pharma did or like with daraprim. and then there’s entirely another very american problem of insurance leech layer. taking a very charitable look at it maybe you want to say a thing about availability of american healthcare in general, less charitably, and more likely, you sound like a libertarian antivaxxer
it gives enlightened centrist vibe, maybe that’s why
I meant weaker per kg of body weight, not in absolute terms
Square-cube law means that as they get bigger they need to hunt less (lower rate of heat loss per kg of birb) and get less powerful compared to their size
some common friend spilled the tea in advance perhaps
for ccgt it’s more like 2/3 for gas turbine, 1/3 for steam turbine split, even more uneven for diesel/steam because diesel exhaust is much colder
and fuel cells
as a citizen of a country whose government (-owned company) makes insulin, this reads weird to me
good. generic biosimilars cost like 1/5 of the on-patent thing price
fyi this fella has no training in chemistry or medicine and is just some random ass programmer with severe case of “saving the world from my homelab” symdrome
I don’t think it’s a thing because even the same insulin analogue from different manufacturer can have different dosing
90% of drug candidates fail in clinical trials
couple of reddit threads suggest that this is something you can do, but you have to be evasive around american border guard later if you go in person
i mean i don’t think about it as a separate budget line because if you don’t have that you get police raids and investigation instead of normal business, but yea. insulin is purified using HPLC, so at all times you get some of analytical data about fractions you just made, so some of QC, not all, but already something, already happens at this point
my point is that actual manufacturing costs will be low because biotech scalability logic is that you need to make yeast or something that makes peptide you like and then all you need to do is keep bioreactor alive and happy. lots of what is left is in purification
also it’s an injectable so it’s gonna be kept to some standards that non-injected drugs aren’t. whoever comes up with insulin pill will be printing money
there are multiple short-acting and long-acting insulins because you can’t patent other people’s things, but now it’s all off-patent. just take your stainless steel bioreactor and preparative HPLC, cook up a batch, wait ten years for biosimilar approval and you’re good to go
because unlike with small molecule drugs, when cooking up generic biopharmaceutical there’s extra approval process that amounts to a tiny clinical trial https://en.wikipedia.org/wiki/Biosimilar this and type of economics of scale that there is with biologicals makes manufacture at large scale way more preferable. these requirements were loosened a bit over time
I know not every state can or are willing to do this
this kind of thing scales well, i see no reason why after california has it set up, other states couldn’t get insulin from them, or chip in
it might just be in glass vial and freezing broke it
it can be bought in italy as a cleaning agent without going through entire process as for reagents purchase iirc