Rising carbon dioxide in the atmosphere may be leaving a measurable imprint inside the human body. Researchers analyzing more than two decades of U.S. health data found that blood bicarbonate levels have climbed about 7% since 1999, while calcium and phosphorus have declined—changes that closely track increasing atmospheric CO2.
Leaded gasoline had a big impact https://today.duke.edu/2022/03/lead-exposure-last-century-shrunk-iq-scores-half-americans
CO2 I imagine very similar lower individual impact but way more widespread.