I use Bazzite as my only desktop OS at the moment (I have multiple headless servers with either Fedora or Debian), and have been using Fedora atomic for awhile before that. I noticed no significant change in general purpose computing when switching from Fedora atomic (Kinoite) to Bazzite, other than all the non-free codecs and drivers I would have installed in Fedora already being present in Bazzite. If anything, that improved my experience. I don’t even game much, it’s just something I do occasionally, though I’ve been using Linux exclusively for over a decade now, so I can’t say I get frustrated enough fixing minor things that I’d really remember things that are easy for me to fix, but potentially difficult for someone new to fix. Honestly, the only time I’ve really had to fix stuff in my recollection is from bash scripts I wrote in other distros no longer working, and since it’s atomic, I chose to rewrite for the tools available instead of layering unnecessary packages. Certainly not something I’d imagine someone new doing.

As far as most software goes, you install it via Flatpak, so the experience should be identical across different distros.