My answer to this used to be Panty + Stocking, but they have a new season coming out on my birthday!

I guess now my pick is 009-1. I really love a good East vs West rivalry, and having a femme James Bond doing espionage in a world where the Soviets never collapsed really hit a lot of notes. I gets pretty weird towards the end, and I wish they had another season to go even weirder.