My secret to high uptime:

while True:
    try:
        main()
    except:
        pass

Not necessarily a trick that’s always useful but I always forget this.
You can get async REPL by calling python -m asyncio.

Also, old trick - in need of simple http server serving static files?
python -m http.server

Don’t need to activate your venv to use it.

Just use venv/bin/python my-file.py from a script or a terminal from your project root.