For me I use the following:
Temporary containers - This add-on is so amazing and really helps when signing into multiple accounts
UBlock Origin - Add blocker, probably the best available
Dark Reader - Helps to make the web a little more readable and less harmful to the eyes
I’m not the biggest extension geek but I’ve been happy with uBlock Origin for years.
The default filters are usually fine, supports adding new external filter lists, allows one to add custom rules via GUI (block that element I’m clicking on), haven’t ever had an issue with YouTube ads and so on.
uBlog Origin and a Dark Reader-style are my two go-to"always extensions.