Baldur's Gate 3 has a secret, brutal game over scene for players who somehow overcome every safeguard to permanently lose a critical item
www.pcgamer.com
With this macguffin's loss, the thread of prophecy is severed. (Spoilers!)

YouTuber BOB_BestOfBugs, however, realized that there’s nothing stopping you from putting a Netherstone into a container like a crate or a sack (crucial to the Shadowboxing speedrun tech) and then getting rid of that container. I was able to replicate the trick in my own game, but curiously I only got the game over on losing my second Netherstone⁠, so watch out for potentially soft locking yourself here.

What follows is the most luxurious sort of “you messed up, big time” scene you could possibly ask for, shades of firing a mining laser that wipes out all of humanity in System Shock and its remake.

(SPOILERS) YouTube Link